Melatonin increases magnesium concentrations in white adipose tissue and pancreas of diabetic obese rats

This study reveals for the first time that melatonin intake increases Mg concentrations in subcutaneous lumbar, visceral, omentum, and gonadal adipose tissue and in the pancreas. These findings may be related to an improvement in the homeostatic regulation of adipocytokines produced by white adipose tissues, and to a reduction in plasmatic oxidative stress, which would lead to a decrease in insulin resistance and improvement in glucose homeostasis. These results open up the beneficial use of melatonin for the development of functional foods to ameliorate glucose homeostasis in obesity-associated diabetes.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research