Saxagliptin Prevents Increased Coronary Vascular Stiffness in Aortic-Banded Mini SwineNovelty and Significance [Arterial Stiffness]

In conclusion, our data show increased coronary conduit vascular stiffness was prevented by saxagliptin and associated with decreased advanced glycation end products, NF-κB, and nitrotyrosine levels in a swine model with potential relevance to HF with preserved ejection fraction.

http://hyper.ahajournals.org/content/72/2/466.short?rss=1

Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Bradley S. Fleenor, An Ouyang, T. Dylan Olver, Jessica A. Hiemstra, Melissa S. Cobb, Gianmaria Minervini, Craig A. Emter Tags: Coronary Circulation, Animal Models of Human Disease, Inflammation, Vascular Biology, Heart Failure Original Articles Source Type: research