EGFR overexpression is not common in patients with head and neck cancer. Cell lines are not representative for the clinical situation in this indication.

Conclusions: Cell lines are not representative of the clinical situation in HNSCC. Larger studies should investigate whether patient subgroups with activating EGFR mutations or overexpression can be identified. PMID: 29989001 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01526K, PaperQianqian Wang, Xiaoli An, Jiahui Xu, Yuwei Wang, Liang Liu, Lai-Han Leung, Xiaojun Yao Selective modulation of individual bromodomains (BDs) by small molecules represents an important strategy for the treatment of various cancers, considering that the BD-containing proteins share common BD structures and distinct... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Dalton Trans., 2018, Accepted Manuscript DOI: 10.1039/C8DT01724G, PaperSrinivasareddy Telukutla, Steven Priv ér, Vijay Venoba Rao, Nedaossadat Mirzadeh, Suresh K. Bhargava A series of gold(I), gold(III) and cationic gold(I) complexes of tris(4-methoxyphenyl)phosphine and tris(2,6-dimethoxyphenyl)phosphine were synthesized and fully characterized by spectroscopic methods. The molecular structures of selected complexes were also determined... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
The idea that lifestyle changes have made the disease more common is a gross exaggeration – but increasingly prevalent. We separate fact from fictionCancer is not up there withthe most likely explanations for what caused the mass extinction 66m years ago of the T rex and the triceratops. That said, at leastone species of dinosaur suffered from blood-vessel tumours – anda 1.7m-year-old toe with bone cancer was discovered in 2016 at a South African world heritage site.Cancer may have been more common in ancient times than we will ever know, because fossilisation will have obliterated most evidence of the disease....
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Cancer research Health & wellbeing Society Medical research Science Life and style Source Type: news
While football (soccer) training may be a potent strategy for health promotion in older men, the considerable risk of injuries may constitute a barrier for referral of clinical populations. The current study explored the attitudes of men with prostate canc...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Recreational and Sports Issues Source Type: news
LUNG cancer symptoms usually begin to show as the condition progresses, with no indications in the early stages. But when they do become apparent the most common sign is a cough, particularly one that won ’t go away or gets worse. There are seven symptoms of the disease all together to look out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
[Premium Times] A Professor of Pharmacognosy at Obafemi Awolowo University, Joseph Aladesanmi, who invented a yet to be clinically tested anti-cancer drug, has decried poor funding of research in Nigeria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Arunkumar G, Deva Magendhra Rao AK, Manikandan M, Prasanna Srinivasa Rao H, Subbiah S, Ilangovan R, Murugan AK, Munirajan AK Abstract MicroRNAs (miRNAs) are reported to function as a major component in the cellular signaling circuit, which regulates epithelial-mesenchymal transition (EMT). Dysregulation of the microRNA-200 (miR-200) family and EMT-associated genes enables tumor metastasis and resistance to therapy. The present study profiled miR-200 family members miR-200a, miR-200b, miR-200c, miR-141 and miR-429, and also several EMT-regulatory genes including zinc finger E-box-binding homeobox (ZEB)1, ZE...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSION: In conclusion, men diagnosed with HNSCC, those with higher grade or advanced state tumor, and those treated by surgery alone are at higher risk of unfavorable outcomes than others and may need more frequent follow-up visits. PMID: 28846014 [PubMed - in process]
Source: Archives of Iranian Medicine - Category: Middle East Health Authors: Tags: Arch Iran Med Source Type: research
Conclusion EBV radiosensitized the p53 mutant tobacco associated head and neck cell line, FaDu. Objectives In the head and neck, HPV is a major risk factor associated with tonsil and base of tongue cancers, while a majority of undifferentiated nasopharyngeal cancers are positive for EBV. Clinically, head and neck tumors positive for HPV or EBV are more radiosensitive than tumors associated with tobacco and alcohol. This study aimed to evaluate whether viral infections can sensitize tobacco-associated head and neck squamous cell carcinoma cell line that harbors multiple mutations, especially TP53, to radiotherapy. Method Fo...
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
Human papillomavirus-associated oropharyngeal squamous cell carcinoma is now recognised as a subtype of head and neck cancer with distinct clinical, molecular and histological characteristics. The majority of these carcinomas are of non-keratinising squamous type but there is a growing number of histomorphologic variants of this disease. Here we describe the clinical, histomorphologic and immunophenotypic features of two cases of human papillomavirus-associated oropharyngeal squamous cell carcinoma demonstrating a clearly delineated biphasic differentiated and undifferentiated phenotype.
Source: Diagnostic Pathology - Category: Pathology Authors: Source Type: research
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