Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets.

CONCLUSIONS: Detecting pathogenic mutations in 13/50 genes examined at comparable frequencies in hrHPV(+) and hrHPV(-) tumors suggest that genetic mechanisms of the two routes of VSCC pathogenesis may be similar, despite being initiated from different premalignant lesions. Importantly, our data provide a rationale for new anti-VSCC therapies targeting the PI3K/AKT/mTOR pathway.
PMID: 29980281 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - July 3, 2018 Category: Cancer & Oncology Authors: Zięba S, Kowalik A, Zalewski K, Rusetska N, Goryca K, Piaścik A, Misiek M, Bakuła-Zalewska E, Kopczyński J, Kowalski K, Radziszewski J, Bidziński M, Góźdź S, Kowalewska M Tags: Gynecol Oncol Source Type: research