Yolk Sac Tumor in Postmenopausal Patients: Pure or Associated With Adenocarcinoma, a Rare Phenomenon

We report two cases, both in older patients. One of the YSTs was associated with high-grade serous and endometrioid carcinoma, while the other case showed pure YST. The YST component showed positivity for SALL4, AFP and Glypican-3 and negative staining for PAX8 supporting a germ cell tumor differentiation; SALL4 and PAX8 markers have not been previously analyzed in this setting. Both tumors recurred within 7 months despite systemic chemotherapy.
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Upper Genital Tract: Case Report Source Type: research