Gene Mutations Dictate Treatment in NCI Clinical Trial

More than 40 patients with mesothelioma have been screened for NCI-MATCH, the novel clinical trial pairing tumor-related gene abnormalities with a drug targeting the corresponding mutation, regardless of cancer type. The multicenter program is the largest precision medicine clinical trial ever conducted, with more than 5,500 patients already participating nationwide. The National Cancer Institute (NCI) sponsors the phase II trial called Molecular Analysis for Therapy Choice (MATCH), which opened in 2015. The study was designed for patients with various solid tumors, myeloma and lymphoma that have progressed after standard-of-care treatment. It was also intended for rare cancers such as mesothelioma to determine if therapies targeting specific gene mutations would work across different cancer types. Matching patients with treatment based upon genetic mutations is not how cancers are traditionally treated. Potential for Future Treatment Advances The early results have been promising. “NCI-MATCH represents the first attempt to systemically leverage next-generation sequencing to explore so many therapies in parallel,” Dr. Keith Flaherty, study chairman and medical oncologist at Massachusetts General Hospital, said in an NCI press release. “We have accelerated the opportunity to find signals of efficacy.” The ongoing trial is enrolling patients at 1,100 community hospitals and cancer centers around the country, including Puerto Rico. Among the drugs being ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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ConclusionAccording to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets and links.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
This study aimed to assess survival after TARE and to identify potential prognostic factors in this patient population. METHODS: Patients with unresectable and chemorefractory CRCLM treated with TARE at our institution between February 2006 and September 2015 were included in the study. Survival rate, hepatic tumor response, and potential prognostic factors were analyzed. RESULTS: In the 43 study patients, the mean follow-up was 15.0 ± 14.2 months, with a median survival of 13.0 months and 1-, 2-, 3-, 4-, and 5-year survival rates of 52.1%, 24.9%, 21.4%, 21.4%, and 7.1%, respectively. The mean activity of yt...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Francesco Cuccia, Gianluca Mortellaro, Rosario Mazzola, Alessandra Donofrio, Vito Valenti, Antonella Tripoli, Domenica Matranga, Antonio Lo Casto, Giuseppe Failla, Giuseppe Di Miceli, Giuseppe FerreraAbstractObjectivesTo investigate whether assessment with two geriatric screening tools shows a correlation with clinical outcomes of patients aged 65 years or more, with early-stage Non-Small Cell Lung Cancer (es-NSCLC) treated with hypofractionated stereotactic radiotherapy.MethodsFrom March 2014 to June 2018 we retrospectively eva...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsTo engage frail older adults with CRC in preoperative exercise programs information on exercise should improve. Exercise programs should be easily accessible and take personal preferences, needs and abilities into account.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Elizabeth J. Siembida, Erin E. Kent, Keith M. Bellizzi, Ashley Wilder SmithAbstractObjectivesPhysical activity (PA) promotes physical functioning and health-related quality of life in older survivors of cancer. Using a population-based sample of Medicare Advantage beneficiaries, we aimed to characterize the survivors who reported discussing PA with their healthcare provider.Materials and MethodsData from the Surveillance, Epidemiology, and End Results (SEER) cancer registries was linked with the 2008–2014 Medicare Health Out...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Date: Tuesday, 05 28, 2019; Speaker: Dr. Thuy Ngo, Research Assistant Professor, Oregon Health and Science University; Building 29B; 1H10
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 06 05, 2019; Speaker: Dana Pe'er, Sloan Kettering Institute; Nancy Allbritton, University of North Carolina at Chapel Hill; Steven Schiff, Pennsylvania State University; Denise Montell, University of California, Santa Barbara; Wendell Lim, University of California, San Francisco; Sanjay Jain, Johns Hopkins University; Christine Hendon, Columbia University; Ramsey Badawi, University of California, Davis; Deepika Mohan, University of Pittsburgh; Alexander Gimelbrant, Dana-Farber Cancer Institute; Amy Palmer, University of Colorado; Gabriel Lander, The Scripps Research Institute; Michael Angelo, Stanford Univ...
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conclusion BSI is a useful asset in stratification of patients with metastatic bone disease. It may also have a place in prediction of biochemical response.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
Conclusion Radioguided pulmonary nodule localization is a reliable procedure with a high rate of success, minimal complications, and lower risk of failures, with no associated mortality or significant morbidity. Our SPECT/CT system is the first to benefit from the technological improvement with successfully implementation and application of fluoroscopy to SPECT/CT.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
Conclusion Our finding of a weak but significant positive correlation between 18F-NaF uptake and arterial calcification suggests that 18F-NaF PET/CT could provide complementary information of active microcalcification for atherosclerosis evaluation in cancer patients.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
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