SAFETY AND IMMUNOGENICITY STUDY OF A SINGLE DOSE OF A MENINGOCOCCAL (GROUPS A, C, W, and Y) POLYSACCHARIDE DIPHTHERIA TOXOID CONJUGATE VACCINE (MEN-ACWY-D) IN HEALTHY JAPANESE PARTICIPANTS.

SAFETY AND IMMUNOGENICITY STUDY OF A SINGLE DOSE OF A MENINGOCOCCAL (GROUPS A, C, W, and Y) POLYSACCHARIDE DIPHTHERIA TOXOID CONJUGATE VACCINE (MEN-ACWY-D) IN HEALTHY JAPANESE PARTICIPANTS. Jpn J Infect Dis. 2018 Jun 29;: Authors: Fukushima S, Kikuchi H, Miyazu M, Hamada A, Ouchi K, Takagi H, Mihara H, Sasaki T, Oka H, Bosch-Castells V, Oster P Abstract Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated the safety and immunogenicity of a single vaccine dose in healthy Japanese adults. The study enrolled 200 participants 2-55 years of age. Immunogenicity was assessed by quantifying seroprotection rates (the proportion of participants with antibody titers ≥1:128 against capsular polysaccharide from all 4 serogroups, measured 28 days after vaccination). Safety endpoints included occurrence, nature, time to onset, duration, intensity, relationship to vaccination, and outcome of solicited and unsolicited adverse events (AEs) and serious AEs (SAEs). Participants included 194 adults, 2 adolescents, and 4 children. Among adults, seroprotection rates for serogroups A, C, W, and Y were 91.2%, 80.2%, 89.1%, and 93.8%, respectively. Seroconversion rates (proportion of participants ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research