A Quantitative Assessment of the Association Between 1425G/A Polymorphism in PRKCH and Risk of Stroke

Abstract Previous studies suggested an association between 1425G/A polymorphism in PRKCH and stroke risk, but the results were inconsistent. To obtain a more precise estimation, we carried out a meta-analysis to analyze the effect of 1425G/A SNP in PRKCH on stroke risk. We searched PubMed, ISI Web of Science, Chinese Biomedical Database, China National Knowledge Infrastructure and WANFANG Data for all eligible case–control studies through April 2014. The odds ratios (ORs), together with the 95 % confidence intervals (CIs), were calculated to evaluate the strength of association between 1425G/A SNP and stroke risk. Overall, seven eligible studies involving a total of 4,574 cases and 5,471 controls were included in our meta-analysis. The results showed that the variant genotypes of 1425G/A polymorphism in PRKCH were significantly associated with a higher risk of stroke in all genetic models (GA vs. GG: OR 1.35, 95 % CI 1.24–1.47, P < 0.001; AA vs. GG: OR 1.50, 95 % CI 1.24–1.82, P < 0.001; GA/AA vs. GG: OR 1.37, 95 % CI 1.26–1.49, P < 0.001; AA vs. GA/GG: OR 1.35, 95 % CI 1.12–1.62, P = 0.002; A vs. G: OR 1.29, 95 % CI 1.21–1.39, P < 0.001). In the subgroup analysis, significantly increased risks were also observed for ischemic stroke, larger sample size (>1,000) and population-based studies. The result of our meta-analysis indicated that the 1425G/A SNP in PRKCH may contribute to susceptibility of stroke, especially ...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research