Improving compliance in adults with epilepsy on a modified Atkins diet: A randomized trial

The modified Atkins diet (MAD) has been effectively used in children and adults with drug-resistant epilepsy (DRE) for almost two decades [1 –7], however long-term compliance remains a major challenge to successful implementation [8,9]. KetoCal® is a ready-to-drink 4:1 ratio (fat: carbohydrates and protein in grams) nutritionally complete liquid formula that can be used as a meal substitute or supplement. A 2011 prospective study of 3 0 children with intractable epilepsy treated with MAD in combination with daily KetoCal® (powder mixed with water or used as a baking mix) found that children tolerated KetoCal® and that there was a>50% seizure reduction in 80% of participants after 1 month [10], which is on average over 30% greater than rates reported previously for MAD alone in pediatric populations [11 –14].

Source: Seizure: European Journal of Epilepsy - June 22, 2018 Category: Neurology Authors: Tanya J.W. McDonald, Bobbie J. Henry-Barron, Elizabeth A. Felton, Erie G. Gutierrez, Joanne Barnett, Rebecca Fisher, MonYi Lwin, Amanda Jan, Diane Vizthum, Eric H. Kossoff, Mackenzie C. Cervenka Source Type: research