Effects of Stroke Unit Care in Acute Ischemic Stroke Patient Ineligible for Thrombolytic Treatment.
Effects of Stroke Unit Care in Acute Ischemic Stroke Patient Ineligible for Thrombolytic Treatment. J Med Assoc Thai. 2017 Apr;100(4):410-7 Authors: Rajborirug K, Tumviriyakul H, Suwanno J Abstract Background: Several trials have verified the benefits of stroke unit (SU) in acute stroke care worldwide. Objective: Compare clinical outcomes and costs of care in acute ischemic stroke patients who were ineligible for thrombolytic treatment (recombinant tissue plasminogen activator-rt PA) in a primary stroke center. Material and Method: A prospective study was conducted in acute ischemic stroke patients, aged 15 years old and above, presenting within 72 hours of onset. At discharge, neurological and medical complications, mortality rate, National Institutes of Health Stroke Scale (NIHSS), Barthel Activities of Daily Living (Barthel ADLs Index), and modified Rankin Scale (mRS) for disability were measured, as well as the length of stay, and cost of hospital care. Results: There were 1,110 acute ischemic stroke patients, 472 subjects (42.52%) in general medical ward (GMW), and 638 subjects (57.48%) in stroke unit (SU). The number of neurological (brain edema, hemorrhagic transformation, or recurrent stroke), and medical complications (gastrointestinal hemorrhage, pneumonia, or pressure sore) in GMW had highly statistical significance (p
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although the underlying molecular mechanisms remain under investigation. Here we demonstrated that endothelial genetic deletion, using EphA4fl/fl/Tie2-Cre and EphA4fl/fl/VeCahderin-CreERT2 mice and vessel painting strategies, implicated EphA4 receptor tyrosine kinase as a major suppressor of pial collateral remodeling, CBF, and functional recovery following permanent middle cerebral artery occ...
Review of English-language articles published from PubMed (MEDLINE) and Google Scholar between January 1, 1985, and January 1, 2019.
Multicenter retrospective analysis of patients entered in the prospective, randomized International Carotid Stenting Study between May 2001 and October 2008.
Currently there is no definitive level I evidence regarding the appropriate management of asymptomatic moderate to severe carotid artery stenosis in the octogenarian patient. In this 5-year review of National Surgical Quality Improvement Program registry data, exceptional “real-world” results are reported with use of carotid endarterectomy (CEA) in this growing cohort.1 The combined stroke and death rate was 2% at 30-day follow-up (stroke rate 1%!), with the authors stating that “age alone should not interdict this modality.”
Regional anesthesia (RA)-induced vasodilation increases the proportion of patients with vein anatomy suitable for arteriovenous fistula (AVF) creation. The functional outcomes of AVFs created with veins initially small for size on preoperative duplex ultrasound mapping ( ≤2.4 mm) that are recruited under RA have not been clearly defined. We aimed to evaluate freedom from revision or thrombosis, time to first cannulation, and reintervention rates of AVFs created with veins recruited after induction of RA.
Conclusions: We speculated that damages to the basal ganglia disrupted the cortico-subcortical circuits that facilitated the transhemispheric communications of language functions, resulting in decreased interhemispheric FC. Consequently, the intrahemispheric FC increased as a possible compensatory mechanism to restore the language functions. PMID: 31955634 [PubMed - as supplied by publisher]
Thailand has found a second case of a new Chinese coronavirus, authorities said on Friday, as they ramped up checks on Chinese visitors, nearly a million of whom are expected for Lunar New Year holidays next week.Reuters Health Information
[IPS] Abuja -The coronavirus outbreak -- which began in Wuhan, China, and causes a pneumonia-like illness -- is raging across Asia, infecting close to 300 people and killing four. It was initially known to be transmitted from animals to human, and was just confirmed to be transmitted from human to human.
A man in Washington State is infected with a new respiratory virus. Federal officials plan to expand screenings for the infection at major airports.
This article reviews results from preclinical and healthy volunteer studies that illustrate the noteworthy properties of apixaban such as a proportional dose-response relationship, low daily fluctuation in plasma concentrations, and safety over a 10-fold dosing range. Additionally, the large phase III trials evaluating the safety and efficacy of apixaban compared to low molecular weight heparin (LMWH) overlapped with and followed by vitamin K antagonist (VKA) warfarin for the treatment and secondary prevention of VTE will be discussed. The key studies that have led to apixaban's current licensing and use will be highlighte...