Copy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysis

Conclusion: High TOP2A expression suggested significant relationship with worse cancer prognosis. Alteration (amplification or deletion) of TOP2A gene was also significantly related to shorter survival of cancer patients. Therefore, TOP2A might be used as an indicator for poor prognosis of cancer in the future.

Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ling Ren, Jingwei Liu, Kaihua Gou, Chengzhong Xing Tags: Research Paper Source Type: research