Chimeric antigen receptor T (CAR T) cells: another cancer therapy with potential  applications in kidney disease and transplantation?

The grand challenge in better treating immune conditions in nephrology, including transplantation and autoimmune kidney diseases, is to establish or re-establish tolerance. Such an outcome would cure the condition and obviate the need for ongoing immunosuppression. In addition, tolerogenic regimens might be both more specific and associated with fewer short- and long-term side effects, which are a major cause of morbidity and mortality in these conditions. In the past, the field of immunology has adapted treatment approaches from oncology, from cyclophosphamide in the 1960s to rituximab in the 2000s.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research