PDCD4 suppresses proliferation, migration and invasion of endometrial cells by inhibiting autophagy and NF- κB/MMP2/MMP9 signal pathway.

PDCD4 suppresses proliferation, migration and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway. Biol Reprod. 2018 Jun 15;: Authors: Li Y, Wang X, Wang X, Wan L, Liu Y, Shi Y, Zhang L, Fang Z, Wei Z Abstract Endometriosis (EM) is a kind of estrogen-dependent disease in reproductive-age women. Ovarian endometriosis is the most common type. Although endometriosis is a benign disease, it shares many similar features with cancers. Programmed cell death 4 (PDCD4), a newly identified tumor suppressor, plays an important role in inhibiting tumorigenesis and tumor progression at the transcriptional and translational levels. To explore the roles of PDCD4 in endometriosis, we detected the expression of PDCD4 in control endometrium and eutopic/ectopic endometrium of ovarian endometriosis patients, and analyzed the effects of PDCD4 on the biological behaviors of endometrial cell lines and primary endometrial cells. The results demonstrated that PDCD4 was downregulated in eutopic and ectopic endometrium of endometriosis patients compared with control endometrium. PDCD4 effectively inhibited the proliferation and colony-forming ability of endometrial cells maybe by inhibiting cell autophagy. In addition, PDCD4 also suppressed the migration and invasion ability of endometrial cells, the mechanism may be related to NF-κB/MMP2/MMP9 signal pathway. Taken together, these results suggest PDCD4 could be involved i...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research