Molecules, Vol. 23, Pages 1452: Anticoagulant Activities of Indobufen, an Antiplatelet Drug
Molecules, Vol. 23, Pages 1452: Anticoagulant Activities of Indobufen, an Antiplatelet Drug
Molecules doi: 10.3390/molecules23061452
Authors:
Jia Liu
Dan Xu
Nian Xia
Kai Hou
Shijie Chen
Yu Wang
Yunman Li
Indobufen is a new generation of anti-platelet aggregation drug, but studies were not sufficient on its anticoagulant effects. In the present study, the anticoagulant activity of indobufen was determined by monitoring the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) in rabbit plasma. We evaluated the anticoagulant mechanisms on the content of the platelet factor 3,4 (PF3,4), and the coagulation factor 1, 2, 5, 8, 10 (FI, II, V, VIII, X) in rabbits, as well as the in vivo bleeding time and clotting time in mice. The pharmacodynamic differences between indobufen and warfarin sodium, rivaroxaban, and dabigatran were further studied on thrombus formation and the content of FII and FX in rats. Animal experiments showed that intragastric-administrated indobufen can significantly reduce the APTT, PT, TT, PF3, FI, II, V, VIII, and X plasma contents. Its inhibitory effect on plasma FII was better than thrombin inhibitor dabigatran with effect on FX better than FXa inhibitor rivaroxaban. These results suggest that indobufen has some anticoagulant effects as strong as some conventional anticoagulants. The mechanism may be related to both exogenous and endogenous coagulation system.
Source: Molecules - Category: Chemistry Authors: Jia Liu Dan Xu Nian Xia Kai Hou Shijie Chen Yu Wang Yunman Li Tags: Article Source Type: research