Frequency and Amplitude Modulation of Resting-State fMRI Signals and Their Functional Relevance in Normal Aging

The intrinsic composition and functional relevance of resting-state blood oxygen level dependent (BOLD) signals are fundamental in research using functional magnetic resonance imaging (fMRI). Using the Hilbert –Huang Transform (HHT) to estimate high-resolution time-frequency spectra, we investigated the instantaneous frequency and amplitude modulation of resting-state fMRI signals, as well as their functional relevance in a large normal-aging cohort (n = 420, age = 21–89 years). We evaluated the cogni tive function of each participant, and recorded respiratory signals during fMRI scans.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research