Estimates of Age-related Memory Decline are Inflated by Unrecognized Alzheimer ’s disease

This study aimed to determine the extent to which estimates of cognitive aging were biased by preclinical AD. Cognitively normal older adults (n = 494) with amyloid-β status determined from PET neuroimaging underwent serial neuropsychological assessment at 18-month intervals over 72-months. Estimates of the effects of age on verbal memory, working memory, executive function, and processing speed were derived using linear mixed models.

Source: Neurobiology of Aging - June 11, 2018 Category: Neuroscience Authors: Karra D. Harrington, Adrian Schembri, Yen Ying Lim, Christa Dang, David Ames, Jason Hassenstab, Simon M. Laws, Stephanie Rainey-Smith, Joanne Robertson, Christopher C. Rowe, Hamid R. Sohrabi, Olivier Salvado, Michael Weinborn, Victor L. Villemagne, Colin Source Type: research