Exercise and weight loss interventions and miRNA expression in women with breast cancer

ConclusionWhile the association between obesity and BC recurrence and mortality has been demonstrated in the literature, mechanisms underlying the link between weight gain and cancer are unclear. Using two independent clinical trials, we identified novel miRNAs associative to BMI and weight loss that  contribute to the development of cancer. Predictive modeling of miRNA targets identified multiple canonical pathways associated with cancer, highlighting potential mechanisms explaining the link between BMI and increased cancer risk.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research