GBA-Associated Parkinson ’s Disease and Other Synucleinopathies

This article describes the structure and function ofGBA, reviews recent literature on the clinical phenotype ofGBA PD, and suggests future directions for research, counseling, and treatment.Recent FindingsSeveral longitudinal studies have shown thatGBA PD has faster motor and cognitive progression than idiopathic PD and that this effect is dose dependent. New evidence suggests thatGBA mutations may be important in multiple system atrophy. Further, new interventional studies focusing onGBA PD are described. These studies may increase the interest of PD patients and caregivers in genetic counseling.SummaryGBA mutation status may help clinicians estimate PD progression, though mechanisms underlyingGBA and synucleinopathy require further understanding.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research