Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP

We recently showed that plasma cholesteryl ester transfer protein (CETP) is mainly derived from VSIG4-positive Kupffer cells. Activation of these cells by the bacterial endotoxin lipopolysaccharide (LPS) strongly decreases CETP expression. As Kupffer cell activation plays a detrimental role in the progression of non-alcoholic fatty liver disease (NAFLD), we aimed to study if metabolic liver inflammation is also associated with a decrease in hepatic and circulating CETP.

Source: Atherosclerosis - June 7, 2018 Category: Cardiology Authors: Lisanne L. Blauw, Zhuang Li, Sander S. Rensen, Jan Willem M. Greve, Aswin Verhoeven, Rico J. Derks, Martin Giera, Yanan Wang, Patrick C.N. Rensen Source Type: research