Few conserved amino acids in the small multidrug resistance transporter EmrE influence drug polyselectivity.

This study reveals that few conserved residues are essential for drug polyselectivity and indicates that aromatic QCC selection involves a greater portion of conserved residues compared to other QCCs.Importance EmrE is an archetypical member of the small multidrug resistance efflux pump family and its members are frequently identified from mobile genetic elements and multidrug resistant plasmids. This study examines conserved residues in EmrE and their MIC to various quaternary ammonium compounds which may shed light on the importance of conserved residues in other EmrE orthologues. In this study, few conserved EmrE residue replacements are required for drug polyselectivity but indicate that many conserved residues that may be important for polyaromatic QCC selection which may be useful for future efflux pump inhibition and inactivation studies. PMID: 29866867 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research