Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study.

CONCLUSION: Our results indicate that in a cohort of patients with a moderate-severe TBI, 1) lesion location specificity (e.g. the temporal lobe) is related to both a high incidence of early seizures and longitudinal development of PTE, 2) early seizures, whether convulsive or non-convulsive in nature, are associated with an increased risk for PTE development, and 3) patients who develop PTE have greater chronic temporal lobe atrophy and worse functional outcomes, compared to those who do not develop PTE, despite matched injury severity characteristics. This study provides the foundation for a future prospective study focused on elucidating the mechanisms and risk factors for epileptogenesis.
PMID: 29859872 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - May 31, 2018 Category: Neurology Authors: Tubi MA, Lutkenhoff E, Blanco MB, McArthur D, Villablanca P, Ellingson B, Diaz-Arrastia R, Van Ness P, Real C, Shrestha V, Engel J, Vespa PM, EpiBioS4Rx Study Group Investigators, Agoston D, Au A, Bell MJ, Branch C, Buitrago Blanco M, Bullock R, Claassen Tags: Neurobiol Dis Source Type: research