Most Women With Breast Cancer Can Skip Chemo, According to New Study

(CHICAGO) — Most women with the most common form of early-stage breast cancer can safely skip chemotherapy without hurting their chances of beating the disease, doctors are reporting from a landmark study that used genetic testing to gauge each patient’s risk. The study is the largest ever done of breast cancer treatment, and the results are expected to spare up to 70,000 patients a year in the United States and many more elsewhere the ordeal and expense of these drugs. “The impact is tremendous,” said the study leader, Dr. Joseph Sparano of Montefiore Medical Center in New York. Most women in this situation don’t need treatment beyond surgery and hormone therapy, and “the rest of them are receiving chemotherapy unnecessarily.” The study was funded by the National Cancer Institute, some foundations and proceeds from the U.S. breast cancer postage stamp. Results were discussed Sunday at an American Society of Clinical Oncology conference in Chicago and published by the New England Journal of Medicine. Some study leaders consult for breast cancer drugmakers or for the company that makes the gene test. MOVING AWAY FROM CHEMO Cancer care has been evolving away from chemotherapy — older drugs with harsh side effects — in favor of gene-targeting therapies, hormone blockers and immune system treatments. When chemo is used now, it’s sometimes for shorter periods or lower doses than it once was. For example, another study at...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Women's Health Source Type: news

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CONCLUSIONS: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high-risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. PMID: 30550346 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Abstract Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Preventive diagnostic studies can only be understood if one is familiar with the statistical terms sensitivity, specificity, prevalence, incidence and bias (especially overdiagnosis and lead time bias). Aspects of radiation protection are es...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Abstract MicroRNA-1204 (miR-1204), a member of the PVT1 region, may improve B cell differentiation and metastasis in breast cancer. However, the role of miR-1204 in NSCLC (non-small cell lung cancer) and its mechanism remain unclear. The GEO public database was first employed to find differentially expressed genes. The expression level of miR-1204 in patient tissues and NSCLC cell lines were determined using qRT-PCR. Cell proliferation assays were performed to investigate the impact of miR-1204 on cell growth. Bioinformatics analysis and dual-luciferase reporter assays were conducted to find potential target genes...
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
More than 30,000 people around the world will be diagnosed with malignant mesothelioma cancer in 2018, according to the latest estimates by the International Agency for Research on Cancer. Almost 26,000 will die from the disease. The numbers on mesothelioma were part of a larger report that included 36 types of cancer. The research covered 185 countries throughout 20 regions. It was published in the November/December issue of CA: A Cancer Journal for Clinicians. An estimated 18.1 million new cancer cases and 9.6 million cancer deaths are expected in 2018, a significant rise from 2012, when the agency published its last stu...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
CONCLUSIONS: Our preliminary data demonstrate that ozone therapy is a valid supportive therapy for fatigue in cancer patients, both during cancer therapy and in a palliative setting with no significant side effects. PMID: 30536352 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
A preoperative chest computed tomography examination of the right breast in a 52 ‐year‐old woman with breast cancer revealed multiple nodules in both lungs. The nodule in the apical segment of the upper lobe of the right lung was larger, at a diameter of approximately 2.1 cm. The patient underwent resection of the right breast, followed by thoracoscopic wedge resection of fo ur pulmonary nodules. Hematoxylin and eosin staining and immunohistochemistry showed that the nodules in the apical and anterior segments of the upper lobe and the paravertebral nodule in the lower lobe of the right lung were primary adenocarcinoma...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
The Canadian Task Force on Preventive Health Care has released breast cancer...Read more on AuntMinnie.comRelated Reading: Canadian task force shifts gears on AAA screening Canadian guidelines support CT lung cancer screening Response: Canadian breast cancer guidelines rely on faulty data Canadian task force advises less frequent breast screening
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 9 December 2018Source: Journal of Molecular StructureAuthor(s): Moideen Musthafa, K.N. Aneesrahman, Balaji Perumalsamy, Thirumurugan Ramasamy, Rakesh Ganguly, Anandaram SreekanthAbstractA new family of o-phenylenediamine substituted bis (aroyl selenourea) 1–3 were synthesised and characterised by spectroscopic methods and Single crystal XRD studies. The 1–3 showed that the synthesised compounds in crystallise in the monoclinic crystal system, and space group present is P 2/c, C 2/c and P 21/c. The computational studies of 1–3 were performed with Density function theory (...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
an-Barmatz Oncogenic properties, along with the metabolic reprogramming necessary for tumour growth and motility, are acquired by cancer cells. Thus, tumour metabolism is becoming a target for cancer therapy. Here, cancer cell metabolism was tackled by silencing the expression of voltage-dependent anion channel 1 (VDAC1), a mitochondrial protein that controls cell energy, as well as metabolic and survival pathways and that is often over-expressed in many cancers. We demonstrated that silencing VDAC1 expression using human-specific siRNA (si-hVDAC1) inhibited cancer cell growth, both in vitro and in mouse xenograft mode...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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