Epigenetic reprogramming to overcome heterogeneity of pancreatic tumor cell subtypes

Objectives Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumor entities. The identification of distinct PDAC subtypes with a similar genetic background had given a first impression that probably epigenetic alterations promote tumor cell heterogeneity. Epigenetic modifications, such as histone modifications, are reversible and therefore attractive targets for cancer therapy.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 9. Experimental pancreatic cancer I Source Type: research