Targeting VPAC1 receptors for imaging glioblastoma

Conclusion: Western blot studies confirmed high VPAC1 expression on the glioblastoma cell lines examined. 64Cu-TP3805 showed excellent labeling efficiency, and high uptake in glioblastoma. Targeting VPAC1 receptors using 64Cu-TP3805 for PET imaging of glioblastoma is a promising approach and calls for further investigation. Acknowledgements: The research, in part, was supported by NIH/NCI R01CA157372 (MLT), NIH/NCI 1S10OD012406 (MLT) and NIH/NCI S10RR23709 (MLT).

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Tripathi, S., Kean, R., Hooper, C., Jin, Y. Y., Wickstrom, E., Thakur, M. Tags: Educational Exhibits Source Type: research