Physiological variations of SUV and textural indices in normal breast tissue in 18FDG PET/CT according to age: a two-centers comparison.

Conclusions:Conclusion: This study in 2 different institutions confirmed the existence of significant differences in SUV, HBI and TI in NBT as a function of age whatever the PET/CT system. ComBat harmonization allowed us to equalize PET biomarkers between PSF and non-PSF reconstructions algorithms without removing the influence of age. Multi-center radiomic studies of breast cancer can be performed using ComBat harmonization and the age covariate should be accounted for in the resulting radiomic models.

Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Boughdad, S., ORLHAC, F., Chekroun, M., Nioche, C., Dirand, A.-S., Champion, L., Buvat, I. Tags: Harmonization and standardization for multicenter studies Source Type: research