Changes in Gene Expression Profiles in Adult Rat Brain Structures after Neonatal Action of Dipeptidyl Peptidase-IV Inhibitors

In this study, using real-time PCR, we evaluated changes in the gene expression of serine protease DPP-IV and prolyl endopeptidase (PREP, EC 3.4.21.26;dpp4 andprep genes), monoamine oxidase А (maoA) and B (maoB), and serotonin transporter (SERT;sert) in the brain structures from 3-month-old rats after postnatal action of DPP-IV inhibitors diprotin A and sitagliptin.Results:Dpp4,sert, andmaoB gene expression increased andmaoA gene expression changed with a tendency to increase in the striatum of rats with neonatal sitagliptin action. The increase ofmaoA gene expression was also shown in the amygdala. An increase inprep gene expression was found in the striatum of rats with the neonatal action of diprotin A, and a decrease inmaoB gene expression was observed in the amygdala. We detected a significant downward trend insert gene expression in the frontal cortex and amygdala, as well as a tendency to increase inmaoA gene expression in the hypothalamus.Discussion: These findings suggest that changes in the expression of the abovementioned genes are associated with the development of anxiety and depression, with increased aggression caused by the neonatal action of diprotin A and sitagliptin.Neuropsychobiology 2017;76:89 –99
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research