Endoplasmic Reticulum Stress in Bipolar Disorder? – BiP and CHOP gene expression- and XBP1 splicing analysis in peripheral blood

Bipolar Disorder (BD) is characterized by mood swings between euphoria and depressed mood (Rothenh äusler HB 2007). The exact mechanisms of these mood swings are still cryptic and must be further elucidated. There is growing evidence from previous in-vitro studies that the Endoplasmic Reticulum (ER), the protein folding factory of the cell, plays a major role in BD (Pfaffenseller et al., 2014, H ayashi et al., 2009, So et al. 2007). The membranous ER network is essential, because it shelters ribosomal protein synthesis, stores calcium for signal transduction and is responsible for the correct folding of proteins.

Source: Psychoneuroendocrinology - May 21, 2018 Category: Psychiatry Authors: Susanne A. Bengesser, Eva Z. Reininghaus, Nina Dalkner, Armin Birner, Helena Hohenberger, Robert Queissner, Frederike Fellendorf, Martina Platzer, Rene Pilz, Carlo Hamm, Alexandra Rieger, Hans-Peter Kapfhammer, Harald Mangge, Bernd Reininghaus, Nathalie M Source Type: research