Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney.

This study aimed at investigating the hypothesis that i) in pediatric patients with UPJO the RAAS is activated prior to surgical relief of the obstruction; ii) in rats with UPJO the RAAS activation is reflected by increased abundance of renal aldosterone-stimulated Na+ transporters; and iii) the injured UPJO kidney allows aberrant filtration of plasminogen leading to proteolytic activation of the epithelial sodium channel gamma subunit (γ-ENaC). Hydronephrosis due to UPJO in pediatric patients and rats was associated with increased urinary plasminogen/creatinine ratio. In pediatric patients, plasma renin, angiotensin II, urine and plasma aldosterone and urine soluble pro-renin receptor did not differ significantly before and after surgery, or compared with controls. Increased plasmin/plasminogen ratio was seen in UPJO rats. Intact γ-ENaC abundance was not changed in UPJO kidney while low-molecular cleavage product abundance increased. The Na-Cl cotransporter (NCC) displayed significantly lower abundance in the UPJO kidney compared to the non-obstructed contralateral kidney. The Na-K-ATPase alpha-subunit was unaltered. Treatment with an angiotensin-converting enzyme inhibitor (8 days, captopril) significantly lowered blood pressure in UPJO rats. It is concluded that the RAAS contributes to hypertension following partial obstruction of urine flow at the pelvo-ureteric junction with potential contribution from proteolytic activation of ENaC. PMID: 29767556 [PubM...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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CONCLUSIONS: The median age at clinical presentation for various subgroups of anomalies indicates delayed referral. We emphasize the need for prompt referral in order to initiate appropriate therapeutic strategies in children with congenital anomalies of kidney and urinary tract. PMID: 31333211 [PubMed - in process]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
26Objectives: Radical cystectomy with urinary diversion is the Gold standard treatment for invasive muscle bladder cancer. A section of the bowel connected with ureters serves as a reservoir or conduit for urine. A stenosis of the uretero-ileal anastomosis might appear in 1:5 of patients. The identification of patients who would benefit from urological treatment is a significant clinical challenge. We proposed Diuresis-Renography (DR) gravity-assisted with method F+10(sp) (Seated Position), in the subset of patients with urinary diversion and a suspected stenosis of the urinary tract. Methods: 39 patients with CT or ultras...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: General Clinical Specialities: Renal/Hypertension Source Type: research
29Objectives: To investigate the clinical application value of renal dynamic imaging for renal function evaluation in patients with unilateral hydronephrosis. Methods: 63 patients with hydronephrosis were enrolled from Dec.2017 to Aug.2018, then divided into three groups, which were Mild- group (n=18), Moderate- group (n=19) and Severe- group (n=26), according to degree of unilateral hydronephrosis, and 20 healthy subjects were enrolled at same time as control group. All of the subjects were calculated glomerular filtration rate (GFR) by renal dynamic imaging and two-sample method which were recorded as g-GFR and d-GFR. Re...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: General Clinical Specialities: Renal/Hypertension Source Type: research
Conclusions: Percutaneous nephrolithotomy is an effective method for the treatment of upper urinary calculi with few complications. According to the results achieved by an experienced surgeon, the size of stone, staghorn stone, operation time, and degree of hydronephrosis were associated with the bleeding during minimally invasive percutaneous nephrolithotomy. PMID: 30834279 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS: Our results confirm that PUV has a considerable risk for CKD development. Antenatal diagnosis, management of proteinuria and hypertension may modify this progression. But already injured kidneys still have a potential risk. The need for further research to evaluate the impact of any intervention on long term renal outcome is obvious. PMID: 30767491 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Carlström M Abstract BACKGROUND: As much as 20% of all cases of hypertension are associated with kidney malfunctions. We have previously demonstrated in animals and in pediatric patients that hydronephrosis causes hypertension, which was attenuated by surgical relief of the ureteropelvic junction (UPJ) obstruction. This retrospective cohort study aimed to investigate: (1) the proposed link between hydronephrosis, due to UPJ obstruction, and elevated arterial pressure in adults; and (2) if elevated blood pressure in patients with hydronephrosis might be another indication for surgery. MATERIALS AND METHO...
Source: Upsala Journal of Medical Sciences - Category: General Medicine Authors: Tags: Ups J Med Sci Source Type: research
Conclusions: Incontinence, ultrasound abnormalities, and hypertension are highly prevalent in a cohort of Ugandan children with spina bifida, including those with low neurological lesions. These findings support the early and universal initiation of CIC with anticholinergic therapy in a low-income setting. PMID: 30174953 [PubMed]
Source: International Journal of Nephrology - Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research
Traditional Chinese medicine (TCM) is a popular treatment for voiding dysfunction in Eastern countries. However, no previous studies have investigated the effects of TCM on preventing obstructive uropathy in uterovaginal prolapse women. We conducted a large-scale nationwide population-based cohort study to investigate the relationship between TCM and obstructive uropathy in uterovaginal prolapse women. This is a retrospective cohort study with the Taiwan National Health Insurance Research Database (NHIRD). The study population was newly diagnosed uterovaginal prolapse patients between 1997 and 2010 year. Among patients, 76...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Acta Paediatrica,Volume 0, Issue ja, -Not available-.
Source: Acta Paediatrica - Category: Pediatrics Authors: Source Type: research
Conclusion: All the children with MCDK who developed renal injury had eGFR trajectory of increase followed by decline. Renal injury followed the peak eGFR by 3 years on average. This observation is in agreement with the hyperfiltration theory and underscores the importance of following eGFR trajectory closely.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
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