Post-doctoral position at Laboratory of Central and Peripheral Mechanisms of Neurodegeneration, Strasbourg University
A post-doctoral position is available at the Inserm Laboratory of Central and Peripheral Mechanisms of Neurodegeneration (UMR-S1118) team, to study the role of the hypothalamus in amyotrophic lateral sclerosis.The team has previously identified structural and functional deficits in the hypothalamus of ALS mouse models and patients (Vercruysse et al, Brain, 2016; Gorges, Vercruysse et al., JNNP, 2017; for review see Vercruysse et al, Frontiers, 2018) and identified alterations in selected neuronal types in the hypothalamus of mouse models. They now aim at using mouse genetics, combined with pharmacogenetics, to elucidate the contribution of these cell types in ALS and FTD pathophysiology.The project involves the characterisation of mutant mice at the molecular and cellular levels as well as motor phenotyping and energy metabolism.Applicants should hold a doctoral degree in Neuroscience. A solid experience in mouse behaviour and histology is required. The scientific expertise of the candidate should be documented by publications in international peer-reviewed journals. The 3-year position is available inOctober 2018.Applications should include a CV, a letter of intent including a statement of scientific experience and interests, and the names and contact information of two references.Please send your application as a single PDF firstname.lastname@example.org with Postdoctoral position in the subject line.
CONCLUSION: A proportion of ALS patients report utilizing CAM concurrently with conventional treatments. Such use, set amidst a dearth of evidence for the efficacy of CAM in ALS, poses potential direct and indirect risks to patient care, and medical providers should be mindful of and enquire about CAM use when treating ALS patients. PMID: 30248676 [PubMed - as supplied by publisher]
Condition: Amyotrophic Lateral Sclerosis Intervention: Drug: Riluzole Oral Soluble film (ROSF) 50 mg Sponsors: Aquestive Therapeutics; inVentiv Health Clinical; Covance Enrolling by invitation
Brain and Behavior, EarlyView.
In this study, we aimed to compare the immunomodulatory properties of MSCs isolated from the bone marrow of patients suffering from ALS and healthy donors. Moreover, the influence of proinflammatory cytokines on the immunoregulatory functions of MSCs was also evaluated. We found that MSCs from ALS patients and healthy donors comparably affected mitogen-stimulated peripheral blood mononuclear cells and reduced the percentage of T helper (Th)1, Th17 and CD8+CD25+ lymphocytes. These MSCs also equally increased the percentage of Th2 and CD4+FOXP3+ T lymphocytes. On the other hand, MSCs from ALS patients decreased more strongly...
Journal of Cellular Physiology, EarlyView.
AbstractNeuromuscular disorder is a muscular and nervous disorder resulting in muscular weakness and progressively damages nervous control, such as amyotrophic lateral sclerosis (ALS) and myopathy (MYO). Its diagnosis can be possible by classification of ALS, MYO, and normal electromyogram (EMG) signals. In this paper, an effective method based on variational mode decomposition (VMD) is proposed for identification of neuromuscular disorder of EMG signals. VMD is an adaptive signal decomposition which decomposes EMG signals nonrecursively into band-limited functions or modes. These modes are used for extraction of spectral ...
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Miguel Leal Rato, Gonçalo S Duarte, Tiago Mestre, Mamede de Carvalho, Joaquim J Ferreira
Publication date: Available online 18 September 2018Source: Pharmacological ResearchAuthor(s): Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong ZhouAbstractIn amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93 A/cpYFP) tha...
International Journal of Clinical Practice, EarlyView.
Conclusions Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression.