Post-doctoral position at Laboratory of Central and Peripheral Mechanisms of Neurodegeneration, Strasbourg University
A post-doctoral position is available at the Inserm Laboratory of Central and Peripheral Mechanisms of Neurodegeneration (UMR-S1118) team, to study the role of the hypothalamus in amyotrophic lateral sclerosis.The team has previously identified structural and functional deficits in the hypothalamus of ALS mouse models and patients (Vercruysse et al, Brain, 2016; Gorges, Vercruysse et al., JNNP, 2017; for review see Vercruysse et al, Frontiers, 2018) and identified alterations in selected neuronal types in the hypothalamus of mouse models. They now aim at using mouse genetics, combined with pharmacogenetics, to elucidate the contribution of these cell types in ALS and FTD pathophysiology.The project involves the characterisation of mutant mice at the molecular and cellular levels as well as motor phenotyping and energy metabolism.Applicants should hold a doctoral degree in Neuroscience. A solid experience in mouse behaviour and histology is required. The scientific expertise of the candidate should be documented by publications in international peer-reviewed journals. The 3-year position is available inOctober 2018.Applications should include a CV, a letter of intent including a statement of scientific experience and interests, and the names and contact information of two references.Please send your application as a single PDF email@example.com with Postdoctoral position in the subject line.
Parkinson's Disease (PD) is diagnosed clinically. Reliable non-invasive PD biomarkers are actively sought. Transfer RNAs produce short non-coding RNAs, the tRNA-derived fragments (tRF). tRF have been shown to play diverse roles, including in Amyotrophic Lateral Sclerosis, and the response to ischemic stroke. Rich tRF populations are being reported in biofluids. We explored the possibility that tRF can serve as non-invasive biomarkers for PD.
Publication date: Available online 23 May 2019Source: NeuroscienceAuthor(s): Lina Yan, Weijing Qi, Yaling Liu, Fuling Zhou, Yafei Wang, Lin Bai, Xiaomeng Zhou, Can Sun, Xiangyu Nie, Shiru Duan, Jina Ran, Juan Chen, Yingxiao Ji, Yakun Liu, Zhongyao Li, Yuanyuan Li, Qingxin WangAbstractAs an adult-onset neurodegenerative disease, amyotrophic lateral sclerosis (ALS) results in progressive muscular atrophy and paralysis. However, the mechanism of ALS has not yet been elucidated, and no cure has been found. Research has revealed that a mutation of the Cu/Zn superoxide dismutase (SOD1) gene is linked to familial ALS and that pot...
Conclusion: Our results do not support the causal role of genetically increased or decreased BMI on the risk of ALS.
(Sanford Burnham Prebys Medical Discovery Institute) New research on amyotrophic lateral sclerosis (AML) has revealed that a protein called membralin plays a key role in the disease process. The study, published in Journal of Clinical Investigation, suggests that membralin-boosting gene therapy is a potential therapeutic direction to treat this often deadly disease.
ConclusionThese findings collectively suggested that initial symptoms influenced phenotypes in SCA3 and that neurodegeneration in different parts of brain may induce different disease severity in SCA3.
Conclusion: Overall, and even though we must account for the limitations of the indirect methods and models used for prevalence estimation, we probably have a very high ALS/MND prevalence in Portugal. It would be important to create registries, particularly in rare diseases, for better organization and distribution of healthcare services and resources, particularly at the level of ventilatory support.Neuroepidemiology
Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...
Conclusion: This study provides evidence that not all ALS patients show contiguous clinical or electrophysiological spread patterns. The electrophysiological spread pattern can affect the functional staging in ALS patients. Keywords：Amyotrophic lateral sclerosis, prion-like mechanism, electrophysiology, spread pattern
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease in adults and has also been proven to be a type of conformational disease associated with protein misfolding and dysfunction. To date, more than 150 distinct genes have been found to be associated with ALS, among which Superoxide Dismutase 1 (SOD1) is the first and the most extensively studied gene. It has been well established that SOD1 mutants-mediated toxicity is caused by a gain-of-function rather than the loss of the detoxifying activity of SOD1. Compared with the clear autosomal dominant inheritance of SOD1 mutants in ALS, the po...