Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

ConclusionsOur results show that in low transmission settings, naturally acquired antibody responses against the CSP repeats ofP. vivax,P. falciparum, andP. malariae in a single cross-sectional study may not represent a valuable marker for monitoring recent malaria exposure, especially in an area with a high prevalence ofP. vivax. Furthermore, HLA class II molecules play an important role in antibody response and require further study with a larger sample size. It will be of interest to consider HLA analysis when using serosurveillance to monitor malaria exposure among genetically diverse populations.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research