Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukaemia (ALL) is a prevalent form of pediatric cancer that accounts for 70 –80% of all leukemias. Genome-based analysis, exome sequencing, transcriptomics and proteomics have provided insight into genetic classification of ALL and helped identify novel subtypes of the disease. B and T cell-based ALL are two well-characterized genomic subtypes, significantly marked by bon e marrow disorders, along with mutations in trisomy 21 and T53. The other ALLs include Early T-cell precursor ALL, Philadelphia chromosome-like ALL, Down syndrome-associated ALL and Relapsed ALL.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research