Omega-3 LCPUFA supplementation improves neonatal and maternal bone turnover: A randomized controlled trial

Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Naroa Kajarabille, Manuela Peña, Javier Díaz-Castro, Jose A. Hurtado, Luis Peña-Quintana, Carmen Iznaola, Yessica Rodríguez-Santana, Estefanía Martin-Alvarez, Magdalena López-Frias, Federico Lara-Villoslada, Julio J. Ochoa The aim of this study was to evaluate for the first time the effect of omega-3 LC PUFA supplementation during pregnancy and lactation on bone metabolism in mothers and neonates. 110 pregnant women were divided in two groups: control group (400 mL/day of the control dairy drink); supplemented group (400 mL/day of the fish oil-enriched dairy drink). Plasma bone biomarkers and mineral content in erythrocyte cytosol were assessed. In mothers, DHA supplementation increased OC and OPN levels and decreased IL-6 and TNF-α levels at delivery, increasing PTH levels during lactation. In neonates, DHA supplementation increased ACTH, insulin and leptin, decreasing RANKL and IL-6 in umbilical vein; increased OPG and leptin and diminished TNF-α in umbilical artery; increased OC levels, lowered PTH and TNF-α at birth. DHA supplementation during pregnancy and lactation has beneficial effects on bone turnover in both mother and neonates, representing a non-pharmacological pathway to decrease bone loss. Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research