Mesenchymal stem cell's secretome promotes selective enrichment of cancer stem-like cells with specific cytogenetic profile

Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and cancer recurrence, however the involvement of microenvironment is crucial. Here, we have analyzed how human mesenchymal stem cells (MSCs)-derived conditioned medium (CM) affect colon and melanoma CSCs enrichment and maintenance. Our results strongly suggest that the secretome of CM-MSCs selects and maintains subpopulations with high expression of CSCs markers and ALDH1 activity, low proliferation rates with G1 phase arrest, and notably retain in vivo these properties.

Source: Cancer Letters - May 4, 2018 Category: Cancer & Oncology Authors: Gema Jim énez, Michael Hackenberg, Purificación Catalina, Houria Boulaiz, Carmen Griñán-Lisón, María Ángel García, Macarena Perán, Elena López-Ruiz, Alberto Ramírez, Cynthia Morata-Tarifa, Esther Carrasco, Margarita Aguilera, Juan Antonio March Tags: Original Articles Source Type: research