Prevalence of fosfomycin resistance in methicillin-resistant   Staphylococcus aureus isolated from patients in a university hospital in China, 2013-2015.

Prevalence of fosfomycin resistance in methicillin-resistant  Staphylococcus aureus isolated from patients in a university hospital in China, 2013-2015. Jpn J Infect Dis. 2018 Apr 27;: Authors: Wu D, Chen Y, Sun L, Qu T, Wang H, Yu Y Abstract We aimed to investigate the fosfomycin susceptibility among different methicillin-resistant Staphylococcus aureus (MRSA) clones. Total 293 MRSA isolates obtained from Sir Run Run Shaw hospital during 2013~2015 were tested for fosfomycin susceptibility. The overall fosfomycin resistance rate among these MRSA isolates was 53.2%. For ST5 MRSA isolates (MIC50 >1024mg/L), 91.9% isolates were resistant to fosfomycin. No fosfomycin-resistant isolate was found among the 69 ST59 MRSA isolates (MIC50/90, 0.5/4 mg/L).The fosfomycin resistance rate among the MRSA isolates recovered from skin and soft tissue infection was 19.1%, which was lower than the rates among MRSA isolates from other invasive infections. The fosfomycin resistance rate in community-onset MRSA was 30.2%, which was lower than the rate of 70.7% in healthcare-associated MRSA. One MRSA isolate had fosB7 gene. Most (127/156) fosfomycin-resistant MRSA isolates had deletions in glpT genes. It is important to monitor the fosfomycin susceptibility in MRSA isolates for epidemiological purpose. PMID: 29709971 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research