Mutational analysis of TARDBP gene in patients affected by Parkinson's disease from Calabria

Neurodegenerative diseases are often characterized by the presence of intracellular or extracellular protein aggregates in the central nervous system. Mutations of TARDBP gene have been shown to cause Amyotrophic Lateral Sclerosis and have been reported to present with clinical heterogeneity including parkinsonism. TDP-43 pathology has been observed across a spectrum of neurodegenerative disorders, including Alzheimer's and Parkinson's disease.

Source: Journal of the Neurological Sciences - May 1, 2018 Category: Neurology Authors: Monica Gagliardi, Gennarina Arabia, Rita Nistic ò, Grazia Iannello, Radha Procopio, Lucia Manfredini, Grazia Annesi, Aldo Quattrone Tags: Clinical short communication Source Type: research