Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Curr Opin Chem Biol. 2014 Sep 12;23C:23-30
Authors: Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF
Abstract
Manipulating cytokine function with protein-based drugs has proven effective for treating a wide variety of autoimmune and autoinflammatory disorders. However, the limited ability of protein-based drugs to modulate intracellular targets, including many implicated by studies of the genetics and physiology of these diseases, and to coordinately neutralize redundant inflammatory cytokines, suggests an important and complementary role for small molecules in immunomodulatory drug development. The recent clinical approval of Janus kinase and phosphodiesterase inhibitors, along with emerging evidence from other compound classes, firmly establish small molecules as effective tools for modulating therapeutically relevant proteins that give rise to aberrant cytokine signaling or mediate its downstream consequences.
PMID: 25222143 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - September 12, 2014 Category: Biochemistry Authors: Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF Tags: Curr Opin Chem Biol Source Type: research