174 Metabolic markers in non-melanoma skin cancer cells and the response to photodynamic therapy

Photodynamic therapy (PDT) is used for the treatment of several types of Non-Melanoma Skin Cancer (NMSC), basal and squamous cell carcinoma (BCC and SCC, respectively). Nevertheless, PDT is not always effective and resistant cells may appear after treatment. While normal differentiated cells depend primarily on mitochondrial oxidative phosphorylation to generate energy, cancer cells change this metabolism to an aerobic glycolysis (Warburg effect), which could influence in the response to therapies.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research