Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock

ConclusionWe reported that TREM-1 is expressed and inducible in endothelial cells and plays a direct role in vascular inflammation and dysfunction. The targeted deletion of endothelialTrem-1 conferred protection during septic shock in modulating inflammatory cells mobilization and activation, restoring vasoreactivity, and improving survival. The effect of TREM-1 on vascular tone, while impressive, deserves further investigations including the design of endothelium-specific TREM-1 inhibitors.
Source: Cardiovascular Research - Category: Cardiology Source Type: research