068 Diabetes mellitus type I protects from allergic contact dermatitis in mice

Epidemiological studies revealed a decreased susceptibility to develop an allergic contact dermatitis (ACD) in individuals with autoimmune diseases like type I diabetes or rheumatoid arthritis compared to healthy individuals. However, the clinical relevance of this inverse correlation has not been evaluated so far. In our study, we want to confirm these results by analyzing the induction of a contact hypersensitivity (CHS) reaction, which resembles the ACD in humans, in non-obese diabetes (NOD) mice spontaneously developing an autoimmune insulin-dependent diabetes mellitus was analysed.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research