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Cardiovascular diseases may play a negative role in the prognosis of amyotrophic lateral sclerosis

European Journal of Neurology, EarlyView.
Source: European Journal of Neurology - Category: Neurology Authors: Source Type: research

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AbstractThe blood-brain barrier and the intestinal barrier show signs of disruption in patients with idiopathic Parkinson ’s disease (PD) and animal models of nigrostriatal degeneration, and likewise in amyotrophic lateral sclerosis (ALS) models. A substantial body of evidence shows that defects in epithelial membrane barriers, both in the gut and within the cerebral vasculature, can result in increased vulnerability of tissues to external factors potentially participating in the pathogenesis of PD and ALS. As such, restoration of tissue barriers may prove to be a novel therapeutic target in neurodegenerative disease...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.8b00086
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
This article reviews recent studies at ultra-high field about Alzheimer’s disease (AD), Park inson’s disease (PD), and amyotrophic lateral sclerosis (ALS).Recent FindingsThe research on AD has mainly focused on detecting the thinning of hippocampal layers and the susceptibility effect supposed to be related to beta-amyloid deposition. In patients with PD, atypical parkinsonisms and subjects at risk of developing motor symptoms of Parkinson ’s disease, the main aim was to detect changes in the substantia nigra, probably related to increased iron deposition. In patients with ALS, both brain and spinal cord ...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Publication date: 19 April 2018 Source:Cell, Volume 173, Issue 3 Author(s): Mario Hofweber, Saskia Hutten, Benjamin Bourgeois, Emil Spreitzer, Annika Niedner-Boblenz, Martina Schifferer, Marc-David Ruepp, Mikael Simons, Dierk Niessing, Tobias Madl, Dorothee Dormann Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-β2. In ALS-FUS patients, this is caused by mutations in the nuclear loc...
Source: Cell - Category: Cytology Source Type: research
Authors: Dharmadasa T, Huynh W, Tsugawa J, Shimatani Y, Ma Y, Kiernan MC Abstract INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive muscle weakness and disability, eventually leading to death. Heterogeneity of disease has become a major barrier to understanding key clinical questions such as prognosis and disease spread, and has disadvantaged clinical trials in search of therapeutic intervention. Patterns of disease have been explored through recent advances in neuroimaging, elucidating structural, molecular and functional changes. Unique brain signatures have eme...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Authors: Braga ACM, Pinto A, Pinto S, de Carvalho M Abstract Introduction: The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention. Methods: We included 48 ALS patients randomized in 2 groups: G1 (n = 24), exercise intensity leveled by CPET; G2 (n = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (T1) and 6 months later (T2). We registered oxygen uptake, car...
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
Shoulder pain is a common secondary complication of amyotrophic lateral sclerosis (ALS) that can contribute to functional decline and decreased participation in daily activities. The purpose of this study was to assess the effectiveness of an educational brochure aimed at improving knowledge regarding shoulder pain and dysfunction in people with ALS. Participants completed a preintervention survey with questions regarding their knowledge of how ALS may affect their shoulders. After completing the presurvey, they were mailed a brochure that described shoulder health and range of motion and stretching exercises. Four weeks a...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Education & Administration Source Type: research
Amyotrophic lateral sclerosis (ALS) and the behavioural variant of frontotemporal dementia (bvFTD) commonly share the presence of TDP-43 inclusions. Structural MRI studies demonstrated evidence for TDP-43 pathology spread, but while structural imaging usually reveals overt neuronal loss, perfusion imaging may detect more subtle neural activity alterations. We evaluated perfusion as an early marker for incipient pathology associated brain alterations in TDP-43 proteinopathies. Cortical thickness (CT) and perfusion measurements were obtained in ALS (N=18), pathologically and/or genetically confirmed bvFTD-TDP (N=12), and hea...
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research
Neuropathology and Applied Neurobiology, EarlyView.
Source: Neuropathology and Applied Neurobiology - Category: Neurology Authors: Source Type: research
PMID: 29677557 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
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