Vitamin E TPGS emulsified vinorelbine bitartrate loaded solid lipid nanoparticles (SLN): Formulation development, optimization and in vitro characterization.

CONCLUSION: DOE approach was successfully applied for the development of VRL-SLNs. Enhanced entrapment and anticancer efficacy of TPGS-VRL-SLN can be attributed to emulsifying nature of GMO and inherent cytotoxic nature of TPGS, respectively, which synergizes with VRL. Therefore, TPGS associated SLNs may be potential carrier in cancer chemotherapeutics. PMID: 29629662 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29629662?dopt=Abstract

Source: Current Drug Delivery - April 8, 2018 Category: Drugs & Pharmacology Authors: Maurya L, Rajamanickam VM, Narayan G, Singh S Tags: Curr Drug Deliv Source Type: research