Binge-eating mice reveal obesity clues

(Center for Genomic Regulation) Mice fed on a high-fat or chocolate-based diet show abnormal feeding behaviors such as snacking, bingeing and disrupted eating patterns, according to new research from scientists at the Centre for Genomic Regulation (CRG) and the Pompeu Fabra University (UPF) in Barcelona, Spain. The findings of two studies published back-to-back in the journal Addiction Biology help to explain the behavioral triggers leading to obesity and point towards new ideas for preventing weight gain.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This article provides a review of the preclinical and clinical pharmacology of lorcaserin, including its pharmacokinetic and safety profiles. Preclinical studies with lorcaserin initially focused on simple measures of food intake and body weight gain, but have now expanded to include studies on its effects on appetitive aspects of feeding behaviour and models of binge-eating. A significant number of studies have also shown that lorcaserin alters behaviours related to drug use and addiction, in rodents and non-human primates. Potential clinically-relevant effects of lorcaserin have also been reported in models of pain and s...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: One-third of veterans who were overweight/obese screened positive for engaging in making weight behaviors during military service. Findings provide evidence that efforts to "make weight" are related to binge eating and eating pathology later in life. Future research and clinical efforts should address how to best eliminate unhealthy weight control strategies in military service while also supporting healthy weight management efforts. PMID: 31471885 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
Abstract Despite decades of research, few medications have gained Food and Drug Administration (FDA) approval for the management of substance abuse disorder. The paucity of successful medications can be attributed, in part, to the lack of clearly identified neurobiological targets for addressing the core pathology of addictive behavior. Commonalities in the behavioral and brain processes involved in the rewarding effects of drugs and foods has prompted the evaluation of candidate medications that target neural pathways involved in both drug and eating disorders. Here, pharmacological strategies for the development...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
CONCLUSION: Our results confirm that both FA and clinical level of binge eating are common problems in both overweight/obese patients seeking low-energy-diet therapy and in obese bariatric surgery candidates, justifying the clinical utility of assessing these dysfunctional eating patterns. PMID: 31282493 [PubMed - in process]
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research
Conclusion The experience of failure moments, the struggle with making choices, and negative self-esteem and body image all develop in a different way for each participant. When professionals treat participants by solely focusing on the core symptoms using a one-dimensional cognitive behavioral approach, they may overlook underlying (biological) interactions.
Source: Journal of Addictions Nursing - Category: Addiction Tags: Original Articles Source Type: research
AbstractPurpose of ReviewThe Yale Food Addiction Scale (YFAS) is a self-report questionnaire for the assessment of addiction-like consumption of high-calorie, processed foods. The original scale was developed in 2009 and —for its tenth anniversary—we now review studies using its revised version—the YFAS 2.0.Recent FindingsThe 11 symptoms of food addiction as measured with the YFAS 2.0 demonstrated high internal reliability and a unidimensional structure in several studies, supporting construct validity. Similar to the original YFAS, highest prevalence rates of YFAS 2.0 diagnoses were found in individuals ...
Source: Current Addiction Reports - Category: Addiction Source Type: research
We examined the effects of the independent and combined effects of Zataria Multiflora supplementation and circuit resistance training (CRT) on selected adipokines among postmenopausal women. Forty-eight postmenopausal women were divided into four groups: Exercise (EG, n = 12), Zataria Multiflora (ZMG, n = 12), exercise and Zataria Multiflora (ZMEG, n = 12), and control (CG, n = 12). Participants in experimental groups either performed CRT (3 sessions per week with intensity at 55% of one-repetition maximum) or supplemented with Zataria Multiflora (500 mg every day after breakfast with 100 ml of water), or their combination...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.8b00601
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
Publication date: Available online 8 April 2019Source: NeuroImageAuthor(s): Jessica Weafer, Natania A. Crane, Stephanie M. Gorka, K. Luan Phan, Harriet de WitAbstractIndividuals with impulsive and addictive disorders, including drug addiction, binge eating/obesity, and problem gambling, exhibit both impaired control over behavior and heightened sensitivity to reward. However, it is not known whether such deviation in inhibitory and reward circuitry among clinical populations is a cause or consequence of the disorders. Recent evidence suggests that these constructs may be related at the neural level, and together, increase ...
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionNearly 18% of post-operative patients with LOC eating met food addiction criteria on the YFAS. Co-occurrence of LOC and food addiction following sleeve gastrectomy signals a more severe subgroup with elevated eating disorder psychopathology, problematic eating behaviors, greater depressive symptoms, and diminished functioning. Future research should examine whether this combination impacts long-term bariatric surgery outcomes.
Source: Obesity Surgery - Category: Surgery Source Type: research
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