F235. Immune and Infectious Biomarkers in Psychosis and Clinically High-Risk Psychosis Populations

Immune and infectious contributions to psychiatric disease have been increasingly recognized, but mechanisms are poorly understood. Anti-NMDA receptor encephalitis frequently presents with psychosis, and many studies have investigated the presence of anti-NMDAR antibodies in those with schizophrenia. Infectious diseases such as Lyme disease can present with neuropsychiatric manifestations, and co-morbid Lyme disease and psychosis has been reported in case reports.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

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DiscussionIt is feasible for those with schizophrenia to use their own smartphones to complete cognitive assessments and other measures related to their mental health. While we did not investigate the correlations between these cognitive assessments and other smartphone captured metrics like step count or self-reported symptoms, the potential to longitudinally assess cognition in the context of patients' environments outside of the clinic presents unique opportunities for characterizing cognitive burden in schizophrenia.
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
ConclusionsAutoconnectivity is cognitive state dependent (resting-state vs. task) and mental state dependent (healthy vs. schizophrenia). The concept of autoconnectivity resembles a recurrent neural network and provides a new perspective of functional integration in the brain. These findings may have important implications for understanding of brain function in health and disease as well as for analysis of fMRI time-series.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
In conclusion, our data show for the first time the presence of TBEV in ticks and the related sero-reactivity in goats, confirming the presence of TBEV in the environment of the Canton of Ticino. Further surveillance studies will have to be conducted to follow the persistence of TBEV in this region.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 18 April 2019Source: Veterinary MicrobiologyAuthor(s): Min-Goo Seo, Oh-Deog Kwon, Dongmi KwakAbstractA 23-year-old male Thoroughbred horse at the Korean Military Academy appeared thin with visible rib bones and presented clinical signs of fever, anorexia, lethargy, and severe dehydration. To determine the presence of various febrile disease-causing agents, the 23 cohabiting horses at the academy, including this horse, were subjected to hematology, blood chemistry, and molecular analysis using whole blood samples collected during regular medical check-ups. On the basis of clinical history,...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
CONCLUSIONS: Massa intermedia is present in most of the investigated brains, usually connecting the anterior-superior quadrants of the lateral walls of the third ventricle. Different in shape and size its cross-section is a horizontal ellipse, significantly larger in females. The cross-sectional area and the size of the third ventricle are not in correlation. PMID: 30993663 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
We report on a 38-year-old patient with adult-onset psychotic symptoms on a background of infantile-onset seizures, autistic features and episodic ataxia. Whole-exome sequencing revealed a de-novo novel SCN2A mutation (c.4966T > C, p.Ser1656Pro). This and other SCN2A mutations associated with the schizophrenia phenotype overlap those seen in neurodevelopmental disorders, suggesting a common underlying mechanism. This is the first report of a patient with the entire known SCN2A phenotypic spectrum. We highlight the importance of recognizing the psychiatric phenotypes associated with SCN2A mutations and that...
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
This study aimed to characterize people with schizophrenia by comparing clinical s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Conditions:   Schizophrenia and Related Disorders;   Schizophrenia;   Schizoaffective Disorder;   Brief Psychotic Disorder Interventions:   Device: 1 Hz rTMS;   Device: iTBS;   Drug: Placebo Sponsor:   University of Bern Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Magnetic Resonance Imaging (MRI) can now be used in conjunction with machine learning to predict cognitive development in infants,  according to a  studyrecently published inNeuroImage.White matter is intrinsic to developing brain activity, and the white matter connectome at birth can be used as a neuroimaging biomarker to calculate cognitive development. The group of researchers led by Jessica B. Girault, PhD, from the Carolina Institute for Developmental Disabilities at the University of North Carolina Chapel Hill are searching for imaging biomarkers like white matter to determine risks for neuropsychiatric con...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Conclusion: The results suggest that MTHFR polymorphisms are unlikely to play a major role in the pathogenesis of OCD. Further studies are needed in biochemical data on folate metabolism to clarify the effect of the MTHFR polymorphisms in OCD pathophysiology. PMID: 30992611 [PubMed]
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
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