F235. Immune and Infectious Biomarkers in Psychosis and Clinically High-Risk Psychosis Populations

Immune and infectious contributions to psychiatric disease have been increasingly recognized, but mechanisms are poorly understood. Anti-NMDA receptor encephalitis frequently presents with psychosis, and many studies have investigated the presence of anti-NMDAR antibodies in those with schizophrenia. Infectious diseases such as Lyme disease can present with neuropsychiatric manifestations, and co-morbid Lyme disease and psychosis has been reported in case reports.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research

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Conclusion. Spinal injuries in suicidal jumpers differed from spinal injuries in non-suicidal patients with regard to sex, age, mental health condition, injury location, neurologic damage, and associated injuries. Most survivors of suicidal jumping were young female patients with mental health problems. They tended to have thoracic and lumbar spine trauma rather than cervical trauma with less severe neurological deficits and a higher incidence of accompanying limb injury. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research
Madeline W. Z. Lim, Jimmy Lee
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Ting-Ren Chen, Ying-Chang Chen
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: The possibility of autoimmune encephalitis should be considered in patients with super-refractory status epilepticus. A large proportion of children with suspected AE may be “seronegative.” A trial of immunotherapy should be given to these children when there is a strong clinical suspicion of autoimmune encephalitis even in the absence of cerebrospinal fluid autoantibodies.
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
In this study, based on the gene expression data of JEV infection and the phenome-wide association study (PheWAS) data, we identified 286 genes that participate in the progress of JEV infection using systems biology methods. The enrichment analysis of these genes suggested that the genes identified by our methods were predominantly related to viral infection pathways and immune response-related pathways. We found that bortezomib, which can target these genes, may have an effect on the treatment of JEV infection. Subsequently, we evaluated the antiviral activity of bortezomib using a JEV-infected mouse model. The results sh...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Researchers at Johns Hopkins University discovered that the psychoactive compound in marijuana 'turns on' genes that lead to brain inflammation which in turn may trigger schizophrenia.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conditions:   Encephalitis;   Encephalitis, Viral;   Infectious Encephalitis;   Virus Diseases;   Encephalomyelitis, Venezuelan Equine;   Brain Diseases;   Central Nervous System Diseases;   Central Nervous System Viral Diseases;   Alphavirus Infections;   Togaviridae Infections;   RN A Virus Infections;   Central Nervous System Infections;   Encephalomyelitis;   Physiological Effects of Drugs;   Vaccines;   Encephalomyelitis, ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
 Resident schizophrenic, Michelle Hammer, is a different person when she first wakes up. Before taking her psychiatric medications, she isn’t as coherent, engaged, or energetic as we are accustomed to her being. For this episode – in a controlled environment – Michelle speaks with Gabe before taking her morning psychiatric medications so she can give the audience a small glimpse of how she feels when she starts each day. Listen in to this episode of A Bipolar, a Schizophrenic, and a Podcast now!   SUBSCRIBE &REVIEW “I don’t think unmedicated Michelle is doing that bad!&rdquo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Medications Schizophrenia Source Type: blogs
Conclusions/SignificanceThese preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We present findings from two cases of AMPAR encephalitis that exemplify variability in the disease spectrum, and summarize findings in published cases derived from a systematic literature review. When all patients are considered together, the presence of psychiatric symptoms at presentation portended a poor outcome and was associated with the presence of a tumor. Furthermore, we provide evidence to suggest that the topography of magnetic resonance imaging abnormalities in reported cases mirrors the distribution of AMPARs in the human brain. The potential for neurological improvement following immunomodulatory therapy toget...
Source: Journal of Neurology - Category: Neurology Source Type: research
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