Primary LV Unloading with a Trans-valvular Axial Flow Pump Reduces Infarct Size by Increasing Myocardial Levels of Stromal Derived Factor One Alpha (SDF-1a) in Acute Myocardial Infarction and Limits the Development of Ischemic Heart Failure

We reported that compared to Primary Reperfusion (PR), first reducing myocardial oxygen demand by activating a trans-valvular pump while delaying coronary reperfusion (Primary Unloading; PU) reduces myocardial damage and increases myocardial levels of stromal derived factor 1 alpha (SDF-1a) in models of acute myocardial infarction (AMI). We hypothesize that SDF1a mediates the acute and chronic cardioprotective effects of PU.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: M.L. Esposito, L. Reyelt, X. Qiao, Y. Zhang, K. Morine, S. Annamalai, C. Bogins, P. Natov, A. Patel, E. Rowin, R.H. Karas, N.K. Kapur Source Type: research