Repeated Episodes of Airway Inflammation Augment Acute Rejection and Fibrosis in a Mouse Lung Transplant Model

Chronic lung allograft dysfunction is the major complication after lung transplantation (LTx) that results from a complex interplay of inflammatory and alloimmune factors, culminating in parenchymal and/or airway fibrosis with obliterative bronchiolitis (OB). The lung allograft is constantly exposed to noxious stimuli from the external environment via the airways. We hypothesized that repeated administration of lipopolysaccharide (LPS) would augment alloimmunity and trigger chronic rejection and fibrosis in a mouse minor alloantigen-mismatched orthotopic lung transplant model (C57BL/10 [B10] → C57BL/6 [B6]).

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: T. Watanabe, K. Boonstra, M. Horie, C. Konoeda, Z. Guan, M. Maxim, D. Hwang, M. Liu, S. Keshavjee, S. Juvet, T. Martinu Source Type: research