Improved Lung Preservation in the Organ Care System in a Porcine Transplantation Setting Modelled After the INSPIRE Trial Triggers a Proregulatory T Cell Phenotype

Portable ex vivo lung perfusion (EVLP) is an alternative to cold static storage for graft preservation in lung transplantation. In the clinical INSPIRE trial, lung preservation with the organ care system (OCS) resulted in reduced rates of early PGD. Here, we investigate mechanisms of improved preservation in the OCS focusing on immunological changes in a porcine lung transplant model.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research