Dectin-1 Genotypes are Associated with Decreased CLAD-Free Survival in Lung Transplant Recipients

Dectin-1 is a pattern-recognition receptor encoded by the CLEC7A gene. Cytokine expression triggered by Dectin-1 activation is integral to early pathogen-specific responses. rs16910526 is a CLEC7A single nucleotide polymorphism (SNP) associated with increased risk of invasive fungal disease. Defective pathogen-specific immune responses lead to chronic immune activation. Aspergillus colonization increases the risk of chronic lung allograft dysfunction (CLAD) and death. We hypothesized that rs16910526 polymorphisms yielding decreased Dectin-1 protein expression would reduce CLAD-free survival.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: D.R. Calabrese, T. Chong, J. Singer, D. Torgerson, S. Hays, J. Golden, J. Kukreja, J.R. Greenland Source Type: research