Characterizing the Airway Inflammatory Milieu in Post-Transplantation Lung Biopsies of Cystic Fibrosis Patients: A Single Institution Study of Acute Cellular Rejection

This study aims to characterize this acute airway inflammation in association with ACR status.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research

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We have read with great interest the case report by Pujol et al entitled Synchronous multiple non-small cell lung cancers in an allograft lung recipient [1], about a young cystic fibrosis lung transplant recipient who developed metastatic lung cancer. We would like to comment on this ‘rare’ long-term complication post lung transplantation. Recent registry data from the International Society of Heart and Lung Transplantation showed that the overall incidence of a malignancy post lung transplantation at 1, 5 and 10 years is 5.3%, 19.6% and 31.7% respectively [2] In observation al studies the incidence of lung can...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study we aimed to study LT mortality in CF patients with and without pan-resistant infection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL CLINICAL SCIENCE Source Type: research
Presence of pan-resistant organisms in patients with cystic fibrosis (CF) potentially impacts mortality after lung transplant (LT). We aimed to study LT mortality in CF patients with and without pan-resistant infection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Conclusions: Patients with CF after LT have a reduced maximal exercise capacity without ventilatory or cardiac limitations that persists despite the rehabilitative activity. Our findings showing a low work "efficiency" (low work/VO2 slope) suggest that the reduced exercise capacity could be attributable to muscle-related abnormality in oxygen metabolism in peripheral muscle
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Introduction: The presence of pulmonary hypertension (PH) before lung transplantation (LuTx) is a well known risk factor for primary graft dysfunction (PGD). However, the role of the comprehensive cardiopulmonary hemodynamic assessed before LuTx is limited. We aimed to explore if other hemodynamic variables may have a role in PGD, besides absolute PH.Methods: a retrospective study was conducted at Policlinico Hospital of Milan (Italy) on adults who underwent LuTx for any indication other than cystic fibrosis from 2011 to 2017. PGD was defined as PaO2/FIO2
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Authors: Hsin MKY, Wong CF, Yan SW, Fan KY, Ho CKL, Bhatia I, Au TWK Abstract Clinical lung transplant was first performed in Hong Kong in 1995. In the early years, the volume of activity was very low. There has been a clear trend of increasing volume in the past few years. The recipient pathology is very different from the International Society for Heart and Lung Transplantation (ISHLT) database, with complete absence of cystic fibrosis and alpha-1-antitrypsin deficiency, and a predominance of diseases of the pulmonary circulation. Lymphangioleiomyomatosis (LAM) has a much higher representation on the waiting list...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Workshops Source Type: research
Claire Wineland vowed she wouldn't have a lung transplant, but her decline from cystic fibrosis made her reconsider. Now she's fighting for a chance at survival.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
In this study we investigated regulatory t cells after combined lung and liver transplantation, or after isolated lung transplantation, in cystic fibrosis patients and correlated the findings with long term outcomes
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Patients with cystic fibrosis (CF) may have pulmonary infection with multi-drug resistant organisms (MDRO) potentially impacting post-transplant mortality. Our objective was to study 1-year mortality in CF patients with MDRO compared to those without MDRO lung transplant recipients (LTR) querying the largest international registry.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
More News: Cardiology | Cystic Fibrosis | Heart | Heart Transplant | Lung Transplant | Study | Transplants