Chlamydial Vaccine Technologies

The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.Technologies: 1. A plasmid-deficient Chlamydia trachomatis strain which was shown to be a safe, immunogenic, and protective live attenuated vaccine in a nonhuman primate model. 2. A Chlamydia trachomatis polymorphic membrane protein D (PmpD) based subunit vaccine. 3. A live-attenuated Chlamydia trachomatis plasmid vector deficient in virulence genes, pgp3 and pgp4, which can be used to vaccinate against chlamydia as well as other against other bacterial and viral mucosal pathogens.IC: NIAIDNIH Ref. No.: E-031-2006-0Advantages: Coverage against multiple serovars.Promising preclinical data.Applications: Chlamydia trachomatis vaccine or therapeutic.Vaccine platform technology for mucosal viral and bacterial pathogens.Provider Technology ID: 3188Updated On: Mar 28, 2018Date Published: Wednesday, March 28, 2018Provider Classifications: Publications: Patent Application: 60/760,970PCT/US2007...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research