Cognitive and Language Deficits in Multiple Sclerosis: Comparison of Relapsing Remitting and Secondary Progressive Subtypes.

Conclusion: We conclude that MS patients, irrespective of clinical subtype, have cognitive deficits compared to healthy participants, which become increasingly worse when they convert from RRMS to SPMS.On the contrary,the pattern of impairment remains relatively stable. PMID: 29576812 [PubMed]
Source: The Open Neurology Journal - Category: Neurology Tags: Open Neurol J Source Type: research

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Conclusions: Alexithymia was found in a relatively high percentage in patients with relapse remitting type of multiple sclerosis.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusion: Undiagnosed and under-treated depression is common among older people living with MS and adversely impacts health choices.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsMany of the character strengths in the Peterson and Seligman model enhance QOL in persons with MS, both directly and through their influence on negative effects of MS. The results provide support for the development of character strengths interventions to impact QOL, both directly and indirectly through improvements to MS-related symptoms such as fatigue and depression.
Source: Quality of Life Research - Category: Health Management Source Type: research
The objective is to analyze the associations between cerebellar atrophy, depression, and fatigue in the early phases of relapse-onset multiple sclerosis (RRMS). Sixty-one RRMS patients and 50 healthy controls (HC) were enrolled and clinically evaluated by means of expanded disability status scale (EDSS), Rao ’s brief repeatable battery of neuropsychological tests (BRB-NT), Delis-Kaplan executive function system sorting test, beck depression inventory II (BDI-II), and fatigue severity scale (FSS). The relationships between MRI variables and clinical scores were assessed. Depressed RRMS (dRRMS) had sign ificantly lower...
Source: The Cerebellum - Category: Neurology Source Type: research
The objective is to analyze the associations between cerebellar atrophy, depression, and fatigue in the early phases of relapse-onset multiple sclerosis (RRMS). Sixty-one RRMS patients and 50 healthy controls (HC) were enrolled and clinically evaluated by means of expanded disability status scale (EDSS), Rao's brief repeatable battery of neuropsychological tests (BRB-NT), Delis-Kaplan executive function system sorting test, beck depression inventory II (BDI-II), and fatigue severity scale (FSS). The relationships between MRI variables and clinical scores were assessed. Depressed RRMS (dRRMS) had significantly lower Vermis ...
Source: Cerebellum - Category: Neuroscience Authors: Tags: Cerebellum Source Type: research
This study is a single-center, randomized, controlled, parallel-group study. One hundred and eleven patients with relapsing –remitting MS with current disease activity and stable immunomodulatory therapy or no disease-modifying therapy will be randomized to one of three 18-month dietary interventions: a KD with a restricted carbohydrate intake of 20–40 g/day; a FD with a 7-day fast every 6 months and 14-h daily i ntermittent fasting in between; and a fat-modified SD as recommended by the German Nutrition Society. The primary outcome measure is the number of new T2-weighted MRI lesions after 18&thi...
Source: Trials - Category: Research Source Type: clinical trials
AbstractBackgroundSexual dysfunction (SD) is a stressful and common symptom in women with multiple sclerosis (MS) and affects different aspects of their life,seriously. The purpose of this study was to determine the prevalence, dimensions, and predictor factors of SD in Iranian women with MS.MethodsThis cross-sectional study was conducted in Iran MS Society. Participants were 260 married women who had definite MS. Data were collected using self-report questionnaires, including Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19); Fatigue Severity Scale (FSS); Depression, Anxiety, and Stress Scale-21 (DASS-...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusion: Increasing age is associated with reduced cognitive processing speed whereas comorbidities and sleep behaviors contribute to subjective cognitive performance.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsDiffusion tractography identified abnormalities in the fornix that appears to be affected early and consistently across all three primary MS phenotypes of RRMS, SPMS, and PPMS regardless of Expanded Disability Status Scale, time since diagnosis, or cognitive scores.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study initiated the first steps by assessing the associations between aspects of resiliency and intimacy-related illness intrusiveness in males with multiple sclerosis, and whether they could mediate the latter ’s relationship with depression. Primarily recruited through the North American Research Committee on Multiple Sclerosis Registry, 156 males with multiple sclerosis were included. A subscale from the Illness Intrusiveness Rating Scale (IIRS) measured intimacy-related illness intrusiveness. Resilie ncy was measured with the Multiple Sclerosis Resiliency Scale (MSRS). Correlations were run between the IIRS ...
Source: Sexuality and Disability - Category: Disability Source Type: research
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